For me, this is going to depend a lot on the nature of the licensed setting. Blade Runner is relatively narrow in scope and so I think it works best focusing on the themes and ambiance without, for example, shipping out to wage space wars.
But both Star Wars and Star Trek and even the Marvel Universe are pretty expansive with well-explored main story lines that I do not want to simply reenact. Those settings are fertile and broad enough to generate a lot more than the main sagas. I might be interested in telling stories adjacent to ones percolating in the main IP's storylines - but with separate characters, separate local goals and situations.