I think there might be a few setting specific feats, but I don't expect them to be particularly common. Things that tie to setting specific situations might be limited, like the Red Wizards or Spellfire, but I think most things will be fairly open.
Personally I agree with this concept, because things in a setting book are not always adaptable to other settings. A lot of people complained about the Strixhaven spell Silvery Barbs, but since I never allowed any Strixhaven (or most setting books), I never had any issues with it. The DM can always choose to override this restriction if they want, but it sets the precedent against it.
Personally I agree with this concept, because things in a setting book are not always adaptable to other settings. A lot of people complained about the Strixhaven spell Silvery Barbs, but since I never allowed any Strixhaven (or most setting books), I never had any issues with it. The DM can always choose to override this restriction if they want, but it sets the precedent against it.